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CRPS Treatment: pain in hand for 3 years

General details and patient's info

Age:34 years old at the time of treatment.
Home Country:United States of America.
Illness duration:3 years and a half prior to the Neridronate Treatment.
Symptoms:24/7 burning and throbbing pain; extremely sensitive, cannot touch affected area. Changes in skin temperature and color. Cannot move and all activities are hard or impossible to perform. Pain get worst with tiredness. Sleeping is very difficult and cannot wear dresses covering her shoulder and arm.
Clinical evaluation:CRPS diagnosis. The patient has attended multiple treatments with very minimal temporary relief for her condition. She continues to suffer and is significantly limited in her ability to care for herself and perform ADL..
Time of treatment:October 2018.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient knew about Neridronate treatment from Facebook support groups. After watching a few video testimonials of previous patients, she decided to try it, because all other options had failed.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

2 sessions, 2 hours each, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her first Hotel in Vicenza. Briefing focused on next days.

DAY 2: Rest day, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st Rehabilitation session, 1st visit with the Rheumatologist Professor and 1st Neridronate infusion. In the evening the patient says she can move her arm more easily.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. Visit of Verona’s city center. The patient feels tired, and she needs to rest.

DAY 5: Morning pick-up by her Patient Manager, 3rd Neridronate infusion, 2nd Rehabilitation session, shopping in Verona.

DAY 6: Morning pick-up by her Patient Manager, visit of Vicenza, shopping.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor and last Neridronate infusion.

DAY 8: Morning pick-up by her Patient Manager, drop-off Venice airport to go back home.

Follow up

APRIL 2019: the patient feels much better, she experienced quick improvements and she is back to her job after 4 years of inactivity. She can now wear dresses on her shoulder.

OCTOBER 2019 (1 year after Neridronate treatment): the patient is in remission, back to her life. She keeps on working, she practices yoga as she did before getting sick, she can write and perform everyday tasks, she can finally pick her son up.


This patient had great and quick results after she was administered with Neridronate. She is in full remission. Her life completely changed because she was able to go back to her everyday tasks. She was so much impressed about the effectiveness of her journey and MTI service and reliability that she requested to become an ambassador and spread information to other CRPS warriors. The voice of a person telling his story of battle and finally healing is very important to bring hope and trust to people in pain.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.