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CRPS Treatment: pain in hand for 6 months

General details and patient's info

Age:18 years old at the time of treatment.
Home Country:USA.
Illness duration:6 months prior to the Neridronate Treatment.
Symptoms:Pins and needles sensation; skin texture change; muscle loss; swelling; change in nail growth.
Clinical evaluation:CRPS diagnostic. Patient presents with allodynia.
Time of treatment:August 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s father did a lot of research and found out about Neridronate online, they quickly came to Italy as he read the Neridronate treatment does its best work when administrated close to the event causing CRPS.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

6 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion.

DAY 4: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion.

DAY 5: Rest day in the hotel, in contact with her Patient Manager.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion.

DAY 7: Pick-up by her Patient Manager, check-out and drop-off at the Venice airport for her trip back home.

Follow up

OCTOBER 2019 (2 months after Neridronate treatment): the patient already says her pain is close to 1 or 2. She mentions the swelling is still present but improved.

DECEMBER 2019 (4 months after Neridronate treatment): Unfortunately, the patient fell and sprained her other hand’s wrist. Positively, it did not cause any CRPS. The stress of the event has caused a flare up, but the patient said it was very short and right after that she went back to being practically pain-free. Her other symptoms are completely gone.

FEBRUARY 2020 (6 months after Neridronate treatment): The patient reports a full remission of all pain and symptoms.


The remission is always the result we hope for, in any patient’s case, having had CRPS for 6 months only, it was very easy to achieve for this patient.
The fact that a separate trauma during her months post-treatment did not cause a spreading of the CRPS is an incredible thing, it shows the infusions have made her body stronger.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.