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CRPS Treatment: pain in knee and leg for 9 years

General details and patient's info

Gender:Female.
Age:68 years old at the time of treatment.
Home Country:United States of America.
Illness duration:9 years prior to the Neridronate Treatment.
Cause:Arthroscopic knee surgery.
Symptoms:Swelling, constant pain in the knee, hypersensitivity of leg and foot. Very sensitive to temperature changes. Difficulty walking, pain increases with prolonged walking or standing. Red/purple skin changes.
Clinical evaluation:CRPS diagnosis. Intense throbbing pain and skin discoloration exacerbated by physical therapy. Sharp stabbing pain in both feet. Pain is worse with movement and improves with rest. Burning neuropathic pain in lateral left thigh. Allodynia, hyperpathia. Good strength in the left leg but limited activities due to pain. Unable to bend and cross legs. Osteoporosis.
Time of treatment:March 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient underwent the Neridronate trial in the USA, she received only a third of the prescribed dosage and the research was then stopped. She had about 3 months of relief then the pain flared again. All the medications taken to deal with the pain brought her brain fog and gastro-intestinal issues that required more surgeries. Her husband is a neurologist, and he was aware of Neridronate’s efficacy, he wanted his wife to stop taking medications that caused too many side effects.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Pantoprazole infusions; Paracetamol;

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Vicenza. Briefing focused on next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Neridronate infusion. The patient is tired, and she sleeps during the infusion. Some issues with her veins, since she has very small veins that burst easily.

DAY 3: Morning pick-up by her the Patient Manager, 2nd Neridronate infusion. The patient is still tired, but she feels better than yesterday.

DAY 4: Morning meeting with her Patient Manager, rest in the morning because the patient feels nauseous. In the afternoon she feels better and enjoys visiting Vicenza.

DAY 5: Morning pick-up by her Patient Manager and 3rd Neridronate infusion. The woman feels better.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion.

DAY 7: Morning pick-up by her Patient Manager, tour of the Vicenza hills.

DAY 8: Morning pick-up by her Patient Manager and day trip to Verona.

DAY 9: Morning pick-up by her Patient Manager and day trip to Garda Lake.

DAY 10: Morning pick-up by her Patient Manager and drop-off at the Venice airport.

Follow up

JUNE 2019 (3 months after the Neridronate treatment): the patient is still in pain, but she has started decreasing her medications. She exercises for 20 minutes 5 days a week, she feels stronger.

JULY 2019: (4 months after the Neridronate treatment): the patient feels 85% better, she feels strong and keep on exercising. Reducing medications dosage, she has no more brain fog.

MAY 2020: (15 months after the Neridronate treatment): the patient is nearly pain free, she keeps on exercising, feels much better and is back to most of her daily activities.

Conclusion

Neridronate treatment brought important improvements to this patient’s condition and life quality, even after 10 years from the symptoms’ first onset. Her husband is a neurologist, and both still help spreading information on this treatment to CRPS patients, so that they can know there is hope and that remission is possible. The lady reported being nearly pain free, feels much better and is back to most of her daily activities.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.