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CRPS Treatment: pain in left ankle and leg for 18 months

General details and patient's info

Age:48 years old at the time of treatment.
Home Country:USA.
Illness duration:18 months prior to the Neridronate Treatment.
Cause:Left ankle surgery, following a fracture.
Symptoms:Burning pain, numbness, skin sensitivity; tremors and weakness of the left leg; pain is constant and present day and night, increasing in the evening and after longer standing activities; walking is possible but not easy.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:July 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient tried physiotherapy, pain medications, nerve blocks, which did not help much and brought only a mild relief. Her doctor suggested to implant a spinal cord stimulator. Not wanting to take this drastic solution, she researched for other treatments online and found out about Neridronate.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager and short drive to the Vicenza hotel. Check-in, briefing focused on the next treatment days, rest. Light therapy and Biophysical treatment have been installed in her hotel room; her Patient Manager has explained all details on how to operate the machines.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st infusions, 1st Rehabilitation session which she appreciates for the deep knowledge of the therapist. Light therapy and Biophysical treatment in the hotel room.

DAY 3: Morning pick-up by her Patient Manager, 2nd infusions. The patient feels well and comfortable, and in the afternoon, she visits Vicenza center with her patient manager. Light therapy and Biophysical treatment in her hotel room.

DAY 4: Morning pick-up by her Patient Manager, 3rd infusions. 2nd rehabilitation session. The patient reports some side effects, such as general bones ache and nausea; to cope with them the Rheumatologist Professor prescribes Prednisone. The patient rests in hotel during the afternoon and she does Light therapy and Biophysical treatment in her room.

DAY 5: Rest day from treatment: morning pick-up by her Patient Manager, the patient feels better and feels very confident on the treatments she is having in Italy. She goes on a day trip to Valpolicella with her Patient Manager and enjoys a wine tasting experience. Light therapy and Biophysical treatment in her hotel room.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, last infusions; 3rd rehabilitation session. She feels well and the Patient Manager shows her and her caregiver around Verona. Light therapy and Biophysical treatment in her hotel room.

DAY 7: Day trip to Venice with her Patient Manager. Light therapy and Biophysical treatment in hotel room.

DAY 8: Rest day in contact with her Patient Manager, she is quite well and enjoys the hotel pool. Light therapy and Biophysical treatment in her hotel room.

DAY 9: Morning pick-up by her Patient Manager and drop-off at the Venice airport to fly back home.

Follow up

SEPTEMBER 2022 (2 months after treatment): the patient has a pain decrease and she is able to reduce her daily dose of medications. She says that her daily activities are easier to perform.

OCTOBER 2022 (3 months after treatment): the pain levels keep on lowering down, the patient feels very trustful in further improvements.

JANUARY 2023 (6 months after treatment): the patient reports a reduction of pain and symptoms of 70% – 80%. She still experiences rare flare up days but they never last too long as before the treatments.

JULY 2023 (12 months after treatment): pain level settled on a mild 2/10 and the patient says she did not experience any flare ups in the past 3 months.


After a year and a half of very frequent flare ups and daily high levels of pain, this patient has managed to experience a 80% reduction of pain and other symptoms. She actually mentioned her skin sensitivity has completely resolved. She now manages to take less pain medication and is managing her daily life normally. This was a very successful case.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.