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CRPS Treatment: pain in left arm for 3 years

General details and patient's info

Age:37 years old at the time of treatment.
Home Country:United Kingdom.
Illness duration:3 years prior to the Neridronate Treatment.
Cause:Sprained wrist.
Symptoms:Burning sensation; intense pain; patient’s hand is swollen and bright purple; sensitivity to weather changes.
Clinical evaluation:CRPS. 
Time of treatment:February 2020.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient is a physiotherapist specialized in chronic pain. She was well aware of CRPS as she was of other chronic pain conditions, so when the first symptoms appeared after her sprained wrist seemed to be completely healed, she was alert and knew to see a neurologist quickly. The doctor confirmed her diagnosis, she then tried various treatment in the UK, none of which gave her the relief she was looking for. Unfortunately, she had to suspend her professional activity as the pain was becoming unbearable. She found out about Neridronate online and decided it was her best option.  

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

DAY 1: Arrival at the Verona airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. The patient was looking forward to her rehabilitation session, given her previous occupation. She was pleasantly surprised with Italian physiotherapy techniques.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. Tourism in Lake Garda.

DAY 5: Rest day in the hotel, in contact with her Patient Manager.

DAY 6: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. Tourism in Verona.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Pick-up by her Patient Manager, check-out and drop-off at the Verona airport for her trip back home.

Follow up

APRIL 2020 (2 months after Neridronate treatment): the patient refers to a very good improvement in pain level and mobility.

AUGUST 2020 (6 months after Neridronate treatment): The patient refers to a full remission of symptoms, she says her hand feels much more powerful now and she has regained all her mobility.

DECEMBER 2020 (9 months after Neridronate treatment): Patient confirms she still is in full remission and has gotten back to her previous job as a physiotherapist.


This is a heart-warming case. This patient had to stop practicing her beloved occupation because of the pain level of she was in. The Neridronate has worked wonders on her and allowed her to go into a full remission of her symptoms and get back to being a physiotherapist.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.