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CRPS Treatment: pain in left foot for 7 months

General details and patient's info

Age:25 years old at the time of treatment.
Home Country:USA.
Illness duration:7 months prior to the Neridronate Treatment.
Cause:She thinks it started when someone stomped on her foot at a concert.
Symptoms:Symptoms started in the foot and are now going up to the knee. Sharp burning pain; change in color; swelling of the foot; cannot bear weight on the leg.
Clinical evaluation:CRPS. 
Time of treatment:January 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

This young woman had suffered from CRPS for 7 months and had just gotten a diagnosis, luckily, she found out about Neridronate before having tried any other treatment, and quickly came to Italy to help her CRPS.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Tourism in Venice all day with Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. Tourism in Verona.

DAY 5: Rest day in the hotel, in contact with her Patient Manager.

DAY 6: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Rest day in the hotel, in contact with her Patient Manager.

DAY 9: Pick-up by her Patient Manager, check-out, and drop-off at the Venice airport her his trip back home.

Follow up

APRIL 2022 (3 months after Neridronate treatment): The patient refers to improvement in her pain levels and says she can see the swelling getting down week by week.

JULY 2022 (6 months after Neridronate treatment): The patient confirms being in full remission of all symptoms and has been for about a month now.

DECEMBER 2022 (11 months after Neridronate treatment): The patient wrote to us for Christmas wishes, and confirmed she is still in remission, thanking all the team for “your amazing work”.


This patient had an incredibly quick recovery time, leading her to a full remission in just 5 months. Every CRPS case is different, remission have been achieved with the Neridronate treatment, for cases of diverse types. This young woman is now able to run again, on a leg she could not even stand on few months ago.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.