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CRPS Treatment: pain in left leg and left arm for 12 years

General details and patient's info

Age:49 years old at the time of treatment.
Home Country:New Zealand.
Illness duration:12 years prior to the Neridronate Treatment.
Cause:Piece of metal fell on her leg at work.
Symptoms:Symptoms started in her left leg, which is still now the main affected area in which the patients feels pain she describes as 9/10 daily, burning, constant pins and needles, skin sensitivity, swelling, change in color, important muscle loss and loss of mobility. Symptoms then spread to her left arm, less aggressively than in the leg: she describes the pain as 5/10, and only notices high skin sensitivity on this area as for other symptoms.
Clinical evaluation:CRPS. 
Time of treatment:May 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient had tried various different treatments, which provided only shot-lasting pain reduction. She then met one of our previous patients on a Facebook group, who told her about her results and experience with us. She then decided to come to us for treatment with her husband and 3 children.  

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Visits with the Nutritionist.
Visits with the Health Coach.

9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. Visit with Nutritionist

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. Visit with Health Coach.

DAY 6: Rest day in the hotel, in contact with her Patient Manager.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor. Visit with Health Coach

DAY 8: Afternoon pick-up by her Patient Manager, drive to Venise for an afternoon of tourism.

DAYS 9-10: Free days, the patient, her husband and their children decide to go back to Venise on Sunday, and rest all day on Monday as they had an early morning flight on Tuesday.

DAY 11: Pick-up by her Patient Manager, check-out, and drop-off at the Venice airport for their trip back home.

Follow up

AUGUST 2023 (3 months after Neridronate treatment): The patient reports great improvements on skin sensitivity in her arm, she also says the pain levels have dropped to 4/10. As for her leg, she feels the pain level have not yet changed.

OCTOBER 2023 (5 months after Neridronate treatment): The patient reports very good improvements: her arm is now at a daily 2/10 pain level and does not present sensitivity anymore. She is able to get back to daily activities in the house without problem. The leg has also shown improvements, she describes her pain level at 5/10 now, and says the pins and needles sensation presents itself very rarely now.

FEBRUARY 2024 (9 months after Neridronate treatment): The patient confirms the previous improvements, with a slight additional improvement on pain levels in the leg. She says she would say her general condition improved of 50-60% and is grateful to have undergone the treatment. She mentions the anti-inflammatory diet she was prescribed has made her feel healthier and generally better.


In longer CRPS cases such as this one, a multidisciplinary approach is often advised to the patient. This one was seen by our Nutritionist and health coach, in order to work on her nutrition and her muscle loss and mobility issues. She has seen a 50-60% improvement of all her symptoms, which is a life-changer for patients who have suffered this long.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.