CRPS Treatment: pain in left wrist for 1 year

General details and patient's info
Why the patient decided to undergo the CRPS Treatment in Italy
Medical treatment the patient underwent in Italy
Daily report of the medical treatment in Italy
Post medical treatment follow up
Conclusion

General details and patient's info

Gender:	Female.
Age:	60 years old at the time of first treatment, 62 at the time of second treatment.
Home Country:	United States of America.
Illness duration:	1 year prior to the first Neridronate Treatment, 3 years prior to the second.
Cause:	Initial onset was a fracture of the 4th and 5th metacarpal on her eft hand
Symptoms:	Severe throbbing pain in entire hand and wrist. Complete relief after first Neridronate treatment. After 2 years pain returns, on and off for few months, swelling, loss of strength and mobility.
Clinical evaluation:	CRPS diagnosis.
Time of treatment:	1st treatment : May 2017 / 2nd treatment : November 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient used to work in the medical field which makes her familiar with doctors and medical studies. When she was diagnosed with CRPS, she found an article on the Neridronate treatment, which is only available in Italy. She came to MTI in 2017 and she had great results: after the second infusion she already felt much better and after few months she had total relief. Unfortunately, after a couple of years she started feeling a gradual return of the pain and stiffness on the left wrist, so she decided to have the second treatment.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

FIRST TREATMENT
4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Pantoprazole infusions; Paracetamol.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

SECONDTREATMENT
4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
4 Pantoprazole infusions; Paracetamol.

2 sessions, 2 hours, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

SECOND TREATMENT

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on next days. Light therapy has been installed in her hotel room; her Patient Manager has explained all details on how to operate the machine.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Neridronate infusion. 1st Rehabilitation session in the hotel’s guest room. She then proceeds with Light therapy in her hotel room.

DAY 3: Morning meeting with her Patient Manager, rest day. She then proceeds with Light therapy in her hotel room.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. She then proceeds with Light therapy in her hotel room.

DAY 5: Morning meeting with her Patient Manager, 2nd rehabilitation session in hotel room. She then proceeds with Light therapy in her hotel room.

DAY 6: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. She then proceeds with Light therapy in her hotel room.

DAY 7: Morning meeting with her Patient Manager, 3rd Rehabilitation session in hotel room. She then proceeds with Light therapy in her hotel room.

DAY 8: Morning pick-up by her Patient Manager, day trip to Venice. She then proceeds with Light therapy in her hotel room.

DAY 9: Morning pick-up by her Patient Manager, day trip to Sirmione. She then proceeds with Light therapy in her hotel room.

DAY 10: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion. She then proceeds with Light therapy in her hotel room.

DAY 11: Morning meeting with Patient Manager, rest day and dinner in Vicenza with all MTI team. She then proceeds with Light therapy in her hotel room.

DAY 12: Morning pick-up by her Patient Manager, drop-off at the Venice airport for her flight back home.

Follow up

NOVEMBER 2019 (immediately after second treatment): the pain is regressing, and movements appear to be free and complete.

JANUARY 2020 (2 months after second treatment): the patient reaches full pain relief.

DECEMBER 2022 (2 years after second treatment): the patient is in full remission: no more pain, her hand looks and move perfectly. She says that MTI and the Italian Neridronate treatment saved her life.

Conclusion

This is one of MTI more successful cases. One of the very few where the patient decided to take Neridronate infusions twice, the second time 2 years after the first.
Years after, she is still in total remission.

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DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.