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CRPS Treatment: pain in leg and foot for 6 years and a half

General details and patient's info

Age:41 years old at the time of treatment.
Home Country:USA.
Illness duration:6 years and a half prior to the Neridronate Treatment.
Cause:Broken ankle.
Symptoms:Burning pain; sensitivity to touch; foot gets swollen; foot turns red often; pain worsen when walking for even a few minutes.
Clinical evaluation:CRPS diagnostic. The patient does not have full range of motion on his right ankle.
Time of treatment:April 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient had tried a dozen treatments and therapies, which never gave him relief, or at least never lasting relief. He found out about Neridronate online and how it is indeed a long-lasting results type of treatment and decided to contact us. 

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion. Tourism in Verona, with company’s wheelchair in order not to get the patient tired.

DAY 3: Morning pick-up by his Patient Manager, 2nd Neridronate infusion.

DAY 4: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion. Tourism in Lake Garda, with company’s wheelchair in order not to get the patient tired.

DAY 5: Rest day in the hotel, in contact with his Patient Manager.

DAY 6: Morning pick-up by his Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion.

DAY 7: Rest day in the hotel, in contact with his Patient Manager.

DAY 8: Pick-up by his Patient Manager, check-out and drop-off at the Venice airport for his trip back home.

Follow up

JULY 2021 (3 months after Neridronate treatment): the patient reports swollen of the foot has completely disappeared, which he is amazed by and so happy about: he can wear shoes for the first time in years.

NOVEMBER 2021 (7 months after Neridronate treatment): the patient reports a pain improvement of about 65%. He says the swelling is still gone, and he hasn’t seen any color change in the last few months. He reports that his range of motion has also improved about 50%.


The patient had suffered from CRPS for 6.5 years, it is understood that the treatment does its “best work” if administrated fast, however patients with longer CRPS cases can still expect improvement in pain levels, His pain levels have improved of about 65% and range of motion 50%,

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.