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CRPS Treatment: pain in leg for 5 months

General details and patient's info

Age:53 years old at the time of treatment.
Home Country:USA.
Illness duration:5 months prior to the Neridronate Treatment.
Cause:Full knee replacement.
Symptoms:Severe and constant pain, sensation of being “tazed”. Feeling that the foot is hit with a bat; gluteus hurts when sitting; the knee gets hot and the foot frozen; leg straightening hurts and triggers foot pain. Standing too long and walking increase the pain and the numbness. Layng on left side is painful. Discoloration of the leg, which turns purple.
Clinical evaluation:Complex Regional Pain Syndrome type 1 of left lower limb.
Time of treatment:November 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s daughter, also suffering from CRPS, came to Italy in 2019 to receive the Neridronate treatment. She reported great outcomes in terms of pain and symptoms reduction and could go back to a normal life. The patient decided to travel here on the base of her daughter important improvements.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

4 Pantoprazole infusions; Paracetamol; Ademetionine I.v.; Hypothalamic Phospholipids.

2 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in the hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patient is asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Vicenza. Briefing focused on the next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion. The patient feels tired, she sleeps during the infusion time.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. The patient sleeps again during the infusion.

DAY 4: Rest day in the hotel, in contact with her Patient Manager.

DAY 5: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patient experiences some side effects and keeps feeling very tired.

DAY 6: T Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, 2nd Rehabilitation session, 4th Neridronate infusion. The patient feels a bit nauseous and very tired. The Rehabilitation Doctor works on her relaxion and by late morning the patient feels much better.

DAY 7: Pick-up by her Patient Manager and drop-off at a Venice hotel, to spend a couple of more days.

Follow up

DECEMBER 2023 (1 month after Neridronate treatment): the patient feels that the treatment is starting to work, and her pain decreases. The patient also got COVID, which made her very uncomfortable.

JANUARY 2024 (2 months after treatment): discoloration below her knee is improving; foot and ankle pain is decreasing. Her left knee is very painful, but the patient manages to differentiate CRPS pain from other types of pain however, and says it seems to be a bad consequence from her knee replacement.

FEBRUARY 2024 (3 months after the Neridronate treatment): the patient is having complicated “mechanical” issues on her left knee. Despite this she reports that the symptoms associated with CRPS are still improving and that she feels the benefits from the Neridronate treatment.


This patient is involved in a “family” CRPS case. There is still much to study on this disease, including the possibility of genetics being involved. The youngest patient developed CRPS after a back fracture at the age of 20 and she is now in remission; her mother (this patient) developed it after surgery at 53 and has seen great improvements from the treatment too.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.