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CRPS Treatment: pain in leg for 5 years

General details and patient's info

Gender:Female.
Age:19 years old at the time of treatment.
Home Country:United States of America.
Illness duration:5 years prior to the Neridronate Treatment.
Cause:Knee dislocation.
Symptoms:Stabbing, burning pain, sometimes shooting pain up and down the leg. Knee bones hurt; skin feels like “hot needles in it”; feels like glass in the knee joint. Pain is exacerbated by touching the area, standing, weight bearing, bending the knee, cold. Muscle spasm. Difficulties to walk and climb stairs.
Clinical evaluation:CRPS diagnosis from a knee injury with official diagnosis in June 2015. Multiple treatment plans have been initiated and failed. The patient was referred to a Pediatric Pain Rehab Clinic, but she is always struggling to cope with the constant pain. The doctor also treated her for depression symptoms associated with her pain.
Time of treatment:November 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s mother, after so many unsuccessful treatments, found out about the Neridronate infusions in Italy. She had the chance to personally talk with previous MTI patients who travelled to Italy for CRPS and had good results. The patient’s doctor also suggested that the Italian protocol could be the best opportunity for her to potentially experience some relief.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Pantoprazole infusions; Paracetamol;

2 sessions, 2 hours each, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on next days. Light therapy has been installed in her hotel room; her Patient Manager has explained all details on how to operate the machine.

DAY 2: Rest day, in contact with her Patient Manager. The patient feels very tired form the long flight. She then proceeds with Light therapy in her hotel room.

DAY 3: Morning pick-up by her Patient Manager, visit of Verona. The patient needs the wheelchair, but she likes the town and enjoys her afternoon very much. She then proceeds with Light therapy in her hotel room.

DAY 4: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor and 1st Neridronate infusion. The patient is afraid of needles and a bit nervous, but it all goes smoothly. She then proceeds with Light therapy in her hotel room.

DAY 5: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. The patient is very tired and a bit nauseous. She then proceeds with Light therapy in her hotel room.

DAY 6: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patient still feels tired and sleeps during the infusion. She is happy because the discoloration of her leg is greatly reducing. 1st Rehabilitation session. She then proceeds with Light therapy in her hotel room.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor and last Neridronate infusion. The patient is tired, but she sees very small improvements which makes her more confident. She then proceeds with Light therapy in her hotel room.

DAY 8: Morning pick-up by her Patient Manager, 2nd Rehabilitation session. She then proceeds with Light therapy in her hotel room.

DAY 9: Morning pick-up by her Patient Manager, day trip to Venice. She then proceeds with Light therapy in her hotel room.

DAY 10: Morning pick-up by her Patient Manager, drop-off Venice airport.

Follow up

DICEMBER 2019 (1 month treatment): pain has dropped from a constant 9-10, to a fairly steady 6-7, for the first time in 5 years. Color and temperature in the leg have been able to regulate themselves to normal as equal to the right leg.

FEBRUARY 2020 (3 months after treatment): the patient had more small improvements and hopes to get even better in following months.

MAY 2020 (6 months after treatment): pain decreased to minimum levels, discoloration and temperature of the area are regular and stable. The patient can now walk longer distances every day. She can sleep well, and she is in a good positive mood. She is now back to working with horses, her passion.

JUNE 2021 (18 months after treatment): the patient is in full remission and she even can run.

Conclusion

After 5 years of being in pain this patient went in full remission, and is even back to running. Herself and her mom keep on spreading information on CRPS and the treatment she had in Italy, to this day.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.