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CRPS Treatment: pain in leg for 6 years

General details and patient's info

Age:68 years old at the time of treatment.
Home Country:USA.
Illness duration:6 years prior to the Neridronate Treatment.
Cause:Laminectomy procedure in 2017.
Symptoms:Constant burning pain which affects the right side of the body, from the foot to the ribs. Hypersensitivity to touch, cannot wear socks, shoes or long pants for too long. Walking is very painful. Showers and wind increase the pain. Cannot sleep with a blanket. Several legs movements cause discomfort.
Clinical evaluation:CRPS diagnosis.
Time of treatment:December 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient was under different pain medications; he tried Physiotherapy, worked with a chiropractor and had a spinal cord stimulator implanted. All of those treatments brought light and temporary relief. His daughter in law found information on CRPS through social media, and she discovered Neridronate infusions.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

4 Pantoprazole infusions; Paracetamol.

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 4: Morning pick-up by his Patient Manager, 2nd Neridronate infusion. The patient feels tired and achy, so the Rheumatologist Professor prescribes Ketorolac infusion to help him. In the afternoon tour of Verona center with the Patient Manager.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion. The patient feels a bit better compared to the previous day and he enjoys visiting the Garda Lake, guided by his manager, with a wheelchair; however, he is glad that he can also walk for a bit without aids.

DAY 6: Morning pick-up by his Patient Manager, 2nd visit with Rheumatologist Professor, 4th Neridronate infusion. The patient also undergoes a Dexa Scan to check on his body composition and bones condition; then he meets the health coach to receive further suggestions on his nutrition and lifestyle improvements.

DAY 7: Morning pick-up by his Patient Manager and day trip to Venice. The patient feels better, he is in a positive mood and alternates walking and the wheelchair.

DAY 8: Pick-up by his Patient Manager, check-out, and drop-off at the Venice airport for his trip back home.

Follow up

DECEMBER 2023 (20 DAYS after Neridronate treatment): the patient’s wife refers that her husband could walk nearly 2 hours, without resting nor feeling pain. The rest of his family too notice that he moves better.

JANUARY 2024 (1 month after Neridronate treatment): the patient has a couple of bad days only but feels generally better. He is determined to find a good physiotherapist and follow the Italian doctors’ suggestions. He is trustful on the next improvements.

FEBRUARY 2024: the patient feels stronger, and he is attending a gym 5 days a week. He is also turning to a mediterranean anti-inflammatory diet.


In order to bring the best results to CRPS patients it is important to involve them in a way that they have an active role on their healing path. For sure Neridronate, together with further tailored therapies, is the starting point to healing but keeping a healthy lifestyle is a booster to the process. While the patients stay in Italy, both the medical professionals and the MTI Patient managers create a “support team” to motivate the patient to play his role; the continuing follow-up after they go home, is another way to keep them focused and positive.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.