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CRPS Treatment: pain in right arm for 1 year

General details and patient's info

Age:37 years old at the time of treatment.
Home Country:USA.
Illness duration:1 year prior to the Neridronate Treatment.
Cause:Surgery on hand following a hiking accident.
Symptoms:Burning pain; swelling; the hand often changes color to red or purple; sensitive to weather change.
Clinical evaluation:CRPS. Patient suffers from diabetes.
Time of treatment:February 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

Simply looking online for available treatments, he found CRPS-Treatment Italy and contacted us to hear about the treatment. This patient is a very sportive person, he loves outdoor sports and has been very depressed since his diagnosis. His mobility has definitely gotten worse with time and the pain doesn’t allow him to do certain sports in which arms are key, such as climbing.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by his Patient Manager, 2nd infusions.

DAY 5: Rest day in the hotel, in contact with his Patient Manager.

DAY 6: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 7: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Rest day in the hotel, in contact with his Patient Manager.

DAY 9: Pick-up by his Patient Manager, check-out, and drop-off at the Venice airport for his trip back home.

Follow up

MAY 2023 (3 months after Neridronate treatment): the patient says he feels his arm getting stronger, and the pain levels lowering.

AUGUST 2023 (6 months after Neridronate treatment): The patient mentions being in near remission, his symptoms are quasi inexistant and he feels like he “got his arm back”.

NOVEMBER 2023 (9 months after Neridronate treatment): The patient is back to climbing, hiking and riding as he was before, he is so thankful for treatment and says he feels like he has gotten a second chance in life.


A near remission is excellent in a case of CRPS in which the patient had it for a bit more than a year, like this man. Getting back to activities as it was before his accident and before the surgery, he told us in an email “it’s as if nothing ever happened, I never thought I would reach this point”.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.