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CRPS Treatment: pain in right arm for 3.5 years

General details and patient's info

Age:61 years old at the time of treatment.
Home Country:USA.
Illness duration:3.5 years prior to the Neridronate Treatment.
Cause:Car accident that fractured his arm.
Symptoms:Burning pain; swelling; the arm and hand often change color to red.
Clinical evaluation:CRPS. 
Time of treatment:July 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

He was losing all hope since none of the treatment he had tried so far were helping him. He looked us up online after searching for a treatment out of state and decided to contact us as soon as possible to organize his treatment week.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by his Patient Manager, 2nd infusions. Tourism in Verona.

DAY 5: Rest day in the hotel, in contact with his Patient Manager.

DAY 6: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions. Tourism in Soave.

DAY 7: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Rest day in the hotel, in contact with his Patient Manager.

DAY 9: Pick-up by his Patient Manager, check-out, and drop-off at the Venice airport for his trip back home.

Follow up

SEPTEMBER 2023 (2 months after Neridronate treatment): The patient says that the pain in his arm has subsided by a 40%, he is able to use it more and the discoloration doesn’t happen as often when using it.

NOVEMBER 2023: (4 months after Neridronate treatment): The patient reports that the pain he experiences has changed, it’s not burning anymore and not as violent. He would say that it decreased by a 60%. He can use his arm much more now; he regained almost all the mobility.

JANUARY 2024 (6 months after Neridronate treatment): The patient says he had an 85% pain decrease and that he does not experience it every day anymore. When he does, it’s usually a 1-2/10, and happens when he pushes himself too much. He has regained all mobility in his arm and can enjoy activities such as baseball.


The patient came to use with a very high pain level and could barely move his arm due to the way it was bent because of the accident. For him to reach an 85% reduction of the pain is amazing, even more when we consider that his mobility is completely back, and he can do everything that he used to do before the accident. He is very satisfied and hoped that it will only get better from now on.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.