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CRPS Treatment: pain in right foot and ankle for 8 months

General details and patient's info

Age:22 years old at the time of treatment.
Home Country:Canada.
Illness duration:8 months prior to the Neridronate Treatment.
Cause:Ankle injury after a fall.
Symptoms:Muscle tightness and muscle spasms; pain increases with activities and putting weight on the foot; Discoloration; burning pain, sensitive to touch; walking is not always possible, a wheelchair is often needed.
Clinical evaluation:CRPS diagnosis. Allodynia in the right ankle. Foot and ankle discoloration, sensitive to light touch.  
Time of treatment:March 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

It took a few months; several doctors and a hospital stay for the patient to receive her CRPS diagnosis. She had to quit her job as a model which got her in a very low mood level. She searched for treatments online and found the Neridronate treatment and read about its promising results. She then contacted us, her family helped with the funds for treatment, and she finally traveled here with her mom.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

4 Pantoprazole infusions; Tylenol.

Daily Report

DAY 1: Arrival at the Verona airport with an easy direct fly, greeted by her Patient Manager and drive to Verona hotel. Check-in, briefing focused on next days, rest.

DAY 2: Pick-up by her Patient Manager, short visit of Verona and dinner in a typical restaurant.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Neridronate infusion.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion.

DAY 5: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patient reports some side effects, such as tiredness and bone ache which she manages with some Tylenol.

DAY 6: Rest day in contact with her Patient Manger. The patient keeps on taking Tylenol and she feels better.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion. The patient feels better, and she does not report side effects anymore.

DAY 8: Morning pick-up by her Patient Manager and tourism in Soave.

DAY 9: Rest day, in contact with her patient manager.

DAY 10: Morning pick-up by her Patient Manager and drop-off at the Verona airport for the flight back home.

Follow up

APRIL 2019 (1 month after treatment): the patient feels better but she still has several muscle cramps.

JUNE 2019 (3 months after treatment): the patient is taking the supplements suggested by our Rheumatologist Professor and the cramping is greatly improving.

AUGUST 2019 (5 months after treatment): the patient is well; she says her pain has lowered greatly and she can now walk quite long distances.

OCTOBER 2019 (7 after treatment): the patient is pain free; she is back at work and does not report any symptoms anymore.


This patient managed to undertake the treatment within the first year of her CRPS diagnosis, which is the ideal scenario with this treatment. In her case, like in so many in the same situation, she managed to reach full remission of symptoms within the months following her treatment week.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.