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CRPS Treatment: pain in right foot and leg for 10 years

General details and patient's info

Age:48 years old at the time of treatment.
Home Country:USA.
Illness duration:10 years prior to the Neridronate Treatment.
Cause:Toe amputation following an incident at his workplace.
Symptoms:His foot is swollen and bright red most of the time; burning and pins & needles in the whole leg; intense skin sensitivity; important muscle loss in the whole leg.
Clinical evaluation:CRPS. 
Time of treatment:Mai 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient had been “cohabitating” (like he liked to say) with CRPS for just over 10 years now, since a terrible work incident that ended up costing him a toe that had to be amputated, when he was 38. He had tried pretty much all the treatments out there over the last years, when he finally came across Neridronate in a group chat with his CRPS support group back home. He then found us online, and contacted us quickly to organize his trip to Italy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
Sessions with Health Coach.
4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
10 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
10 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. Health Coach session.

DAY 4: Morning pick-up by his Patient Manager, 2nd infusions.

DAY 5: Rest day in the hotel, in contact with his Patient Manager.

DAY 6: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions. The patient felt some light side effects, so the touristic afternoon has been cancelled.

DAY 7: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor. Health Coach appointment. Patient feels better but still not up for a touristic afternoon.

DAY 8-9-10: Rest days during which the patient feels better, hence 2 days of tourism are organized, one in Verona, one in Venice. The 10th day is a rest day for the patient, before his flight back.

DAY 11: Pick-up by his Patient Manager, check-out, and drop-off at the Venice airport for his trip back home.

Follow up

AUGUST 2023 (3 months after Neridronate treatment): the patient reports an improvement in skin sensitivity, he is continuing with the exercises advised by the Health Coach.

DECEMBER 2023 (7 months after Neridronate treatment): the patient refers to a general improvement of all symptoms by 60%, and skin sensitivity at the lowest point it has ever been since his CRPS onset.

APRIL 2024 (nearly a year after Neridronate treatment): the patient confirms he has regained muscle intensity during the year, continuing with the exercises shown by the Health Coach during his treatment week. He has reduced his pain med drastically and generally feels a lot better.


After 10 longs years of CRPS battle, this warrior was finally able to get the improvements he was longing for. 60% improvement on all symptoms, and a disappearing skin sensitivity has helped him lowering the pain meds he was taking daily, and the essential visits with the Health Coach taught him how to regain muscle strength without hurting himself.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.