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CRPS Treatment: pain in right foot and leg for 4 years

General details and patient's info

Age:59 years old at the time of treatment.
Home Country:USA.
Illness duration:4 years prior to the Neridronate Treatment.
Cause:Fell on the stairs and broke her foot.
Symptoms:Burning stabbing pain; allodynia; color change; sensitivity to weather change; patient can no walk without crutches.
Clinical evaluation:CRPS. 
Time of treatment:January 2020.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient had been searching for treatments against CRPS for a while when she came across Neridronate and the CRPS-Treatment Italy team. Coincidentally, a friend of hers was working in the American military base in Vicenza, which is where our headquarters are. The gentleman came to see us and had a chat with a Coordinator, who then got in touch with the lady. She came to Italy 2 months after.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Verona airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. Tourism in Garda Lake

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions.

DAY 5: Rest day, the patient went to Vicenza to see her friend, and took the occasion to visit our Headquarters.

DAY 6: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Pick-up by her Patient Manager, check-out, and drop-off at the Verona airport for her trip back home.

Follow up

APRIL 2020 (3 months after Neridronate treatment): patient reports slight improvements in pain levels, the discoloration of her foot is a bit better, and she can feel the allodynia slowly disappear.

JULY 2020 (6 months after Neridronate treatment): the patient refers to 70% improvement of pain level, and disappearance of all other symptoms. She now walks without crutches.

MARCH 2023 (3 years after Neridronate treatment): During a call for the patient’s birthday wishes, she confirms the results from the treatment are lasting and she still is at the same level she was 3 years ago. She is thankful for the treatment and said it got her life back.


After 4 years of suffering CRPS, this patient was lucky enough to find out about Neridronate and come to Italy very quickly. The treatment had good results as it made all symptoms disappear and her pain levels get 70% lower. It allowed her to be able to walk without crutches. Years after, we are still in touch with the patient, and she happily mentions there is no greater feeling that feeling herself again and being able to play with her grandson.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.