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CRPS Treatment: pain in right foot and leg for 8 months

General details and patient's info

Age:20 years old at the time of treatment.
Home Country:USA.
Illness duration:8 months prior to the Neridronate Treatment.
Cause:Horse riding accident, right leg was crushed.
Symptoms:Swelling; sharp pain pins & needles; migraines; change in temperature in the foot.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:October 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient’s doctor had encountered another CRPS patient 2 years before, and had studied the disease, which was back then unknown to him, as well as the available treatments for it. He found out about Neridronate and mentioned it to both patients. This woman then easily found us online and contacted us.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increases micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. Patient feels body aches, Paracetamol taken post infusion.

DAY 6: Rest day in the hotel, in contact with her Patient Manager.

DAY 7: Morning pick-up by her Patient Manager, patient feels better and does not refer to any side effects. 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th infusions.

DAY 9-10: Rest days.

DAY 11: Pick-up by her Patient Manager, check-out and drop-off at the Venice airport for her trip back home.

Follow up

JANUARY 2024 (4 months after Neridronate treatment): Patient report great improvements, her swelling has gone down, as well as her pain levels (she refers to 80% less pain).

APRILL 2024 (6 months after Neridronate treatment): The patient is in full remission.


Undergoing the treatment within a year of the initial trauma that caused CRPS usually gives the best chances of a great outcome, such as, in this case, a total lasting remission of the condition.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.