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CRPS Treatment: pain in right foot for 3 years

General details and patient's info

Age:57 years old at the time of treatment.
Home Country:United States of America.
Illness duration:3 years prior to the Neridronate Treatment.
Cause:Ankle surgery.
Symptoms:Swelling, discoloration; muscle cramps; pain going from the foot to the knee; numbness sensation and burning sensation.
Clinical evaluation:CRPS. 
Time of treatment:September 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient was able to keep active, swimming every day and walking a bit, but felt very uncomfortable, always. He referred a pain level of 5/10, manageable with some medication. However, the disease affected all aspects of his life, including his job as an engineer and his family relations. He was also afraid that his condition could worsen in the future. He contacted a few clinics specialized in CRPS and he trusted the Italian option to be the safest and more promising.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on next days.

DAY 2: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Neridronate infusion. In the afternoon swimming at the hotel pool.

DAY 3: Morning pick-up by his Patient Manager, 2nd Neridronate infusion. The patient feels a bit tired but anyway in the afternoon he swims at the hotel pool.

DAY 4: Morning pick-up by his Patient Manager and 3rd Neridronate infusion. In the afternoon he works in his hotel room, and he swims at the pool.

DAY 5: Morning pick-up by his Patient Manager, 2nd visit with the Rheumatologist Professor and 4th Neridronate infusion. The patient feels tired, and he rests to get ready to go back home.

DAY 6: Morning pick-up by his Patient Manager, drop-off at Venice airport.

Follow up

NOVEMBER 2022 (2 months after Neridronate treatment): the patient refers to a light improvement in pain levels.

MARCH 2023 (6 months after Neridronate treatment): the patient refers to about 50% improvement in his symptoms.


This patient had final results of 50% improvement of his condition compared to prior treatment with Neridronate. During the evaluation of his case, the doctor had advised a more complete treatment plan including neuromuscular rehabilitation, but the patient preferred not to as he had had a bad experience in the states. Our team is specialized in CRPS, that includes our physiotherapist of course, and we have found these sessions to be essential in the path to recovery of all our patients.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.