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CRPS Treatment: pain in right foot for 3 years

General details and patient's info

Age:30 years old at the time of treatment.
Home Country:United Kingdom.
Illness duration:3 years prior to the Neridronate Treatment.
Cause:Right ankle fracture, skating.
Symptoms:Burning pain in foot and leg, up to the knee; swelling and discoloration, sensitive to touch; can wear shoes only for about 2 or 3 hours; walking with crutches, slowly and with frequent stops needed.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:January 2024.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient was, years ago, a professional rollers skater and his goal is now to go back to skating. After being diagnosed with CRPS he underwent physical therapy and took pain medications, which helped only a bit. He was hospitalized for a few weeks in a clinic where he met several therapists, but he only had poor outcomes. One of the clinic therapists suggested him to research Neridronate infusions.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:
3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at Verona airport, meeting with his Patient Manger, check-in at the Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: 1st visit with the Rheumatologist Professor and 1st infusions. 1st Rehabilitation session. The patient feels quite well, in the afternoon took a short walk in Verona, using his crutches, together with his Patient Manager.

DAY 4: 2nd infusions. The patient experienced some flu-like symptoms.

DAY 5: The patient feels better than the previous day, he agrees on a day trip to Venice with his Patient Manager. He can walk a bit with the crutches, taking some stops to rest.

DAY 6: 3rd infusions and 2nd Rehabilitation session.

DAY 7: 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, and 4th infusions.

DAY 8: Check out and drop off Verona airport by Patient Manager.

Follow up

MARCH 2024 (2 months after Neridronate treatment): the patient feels a very light difference in his pain.

APRIL 2024 (3 months after Neridronate treatment): the patient says that his pain is decreased, especially during the night, and he is happy to finally be able to sleep.

MAI 2024 (4 months after Neridronate treatment): the patient says that his pain levels are still decreasing, he can now wear shoes all day long and the swelling has disappeared.


Everyone is different and it is never possible to tell in advance the kind of improvements patients will have after the treatment. Some of them report improvements from the first weeks after the infusions, others take longer to feel some changes. It is important to support them all along, which is why we have our 6 months follow-up plan in place.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.