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CRPS Treatment: pain in right hand and arm for 7 years

General details and patient's info

Age:46 years old at the time of treatment.
Home Country:USA.
Illness duration:7 years prior to the Neridronate Treatment.
Cause:Sprained her wrist during a dancing competition.
Symptoms:Extreme pain in her hand; electric sensation going up her arm; skin sensitivity in the whole arm; cannot wear anything with long sleeves; sensitivity to heat / warmer temperatures.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:March 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

This woman had been a dancer for 20 years, until she sprained her wrist during a dance competition. A sprain that unfortunately led her to fighting CRPS for the next 7 years. She tried spinal cord stimulator, nerve blocks and acupuncture. She had seen results with acupuncture for the first year, but after that it just did not work anymore. She found out about Neridronate very late in her CRPS story, but decided to give it a shot.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. Tourism in Verona

DAY 5: Rest day in the hotel, in contact with her Patient Manager.

DAY 6: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Rest day in the hotel, in contact with her Patient Manager.

DAY 9: Day trip to Venice with her Patient Manager.

DAY 10: Pick-up by her Patient Manager, check-out, and drop-off at the Venice airport for her trip back home.

Follow up

MAY 2023 (2 months after Neridronate treatment): The patient feels her pain changing. She says she does not feel it in the same way, but still feels some kind of pain. Her sensitivity has improved, even though Summer has started to arrive, which usually makes her highly sensitive and prone to flares-up.

JULY 2023 (5 months after Neridronate treatment): The patient refers to a general improvement of her symptoms of about 50%.

JANUARY 2024 (about a year after Neridronate treatment): The patient confirms her improvements are around 50 to 60% compared to her symptoms before the treatment. Her sensitivity on the arm has drastically improved, she can now wear fabric on her arm which means long sleeves are finally a possibility again.


Small things such as being able to wear long sleeves seem like a given for everyone. Except when you are affected by CRPS, and you haven’t been able to wear one in 6 years. This patient has seen a 50% improvement of her symptoms and is finally able to let fabric touch her arm thanks to the improvements in skin sensitivity.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.