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CRPS Treatment: pain in right hand for 5 years

General details and patient's info

Age:62 years old at the time of treatment.
Home Country:USA.
Illness duration:5 years prior to the Neridronate Treatment.
Cause:Wrist fracture.
Symptoms:Symptoms localized in the hand, no spreading. Burning sensation; sharp pain; skin is shiny and red; swelling.
Clinical evaluation:CRPS. 
Time of treatment:December 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient found out about Neridronate in an online forum in which she entered a conversation between some of our previous patients. She then contacted us, and upon the approval of her case, we organized her arrival to Italy for treatment.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

6 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 3: Morning pick-up by her Patient Manager, 2nd infusions.

DAY 4: Rest day in the hotel, in contact with her Patient Manager.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 6: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 7: Pick-up by her Patient Manager, check-out, and drop-off at the Venice airport for her trip back home.

Follow up

FEBRUARY 2023 (2 months after Neridronate treatment): Patient already refers to major improvements in her vasomotor symptoms. Pain levels have slightly improved.

JULY 2023 (7 months after Neridronate treatment): Patient reports a general improvement of 60% of her symptoms and confirms the swelling and color change have completely disappeared.


This woman had an incredibly positive attitude, even though she had been living with pain for the last 5 years of her life. The treatment allowed her to improve 60% of most symptoms, and get rid of the swelling and color change that affected her right hand.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.