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CRPS Treatment: pain in right leg for 4.5 years

General details and patient's info

Age:61 years old at the time of treatment.
Home Country:Australia.
Illness duration:4.5 years prior to the Neridronate Treatment.
Cause:Broken toe.
Symptoms:Deep bone pain in her foot; burning sensation; sensitivity to touch and weather changes, especially to rain; crutches needed to walk; due to the pain and difficulty walking the patient’s posture is affected, causing further issues in her back, neck and shoulder.
Clinical evaluation:CRPS type 1. 
Time of treatment:December 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s relative knew of another woman suffering from CRPS who travelled to Italy to treat her disease 3 years before. They met and she was impressed by the great lasting result she reported, so she decided to undergo the same path.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:
4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, blood works, 1st Rehabilitation session, 1st infusions and Dexa Scan.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions and first meeting with the Nutritionist Doctor, who evaluated the blood works results, the Dexa Scan report and checked on the patient’s lifestyle and needs. In the afternoon short walk in Verona city center.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. The patient today feels a bit nauseous, and she has a light fever. The Rheumatologist Professor prescribe additional medication to help her.

DAY 6: Rest day in the hotel, in contact with her Patient Manager. The patient still feels sick during the day but, after resting, at night she feels better.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions, 2nd visit with the Rheumatologist Professor, 2nd visit with the Nutritionist Doctor who delivers the personalized diet to decrease body inflammation.

DAY 8: Pick-up by her Patient Manager and day trip to Venice. The patient could walk a bit and enjoyed the gondola ride.

DAY 9: Rest day in the hotel, in contact with her Patient Manager. The patient feels better, no more side effects.

DAY 10: Pick-up by her Patient Manager, check-out and drop-off at the Venice airport for her trip back home.

Follow up

JANUARY 2024 (1 months after Neridronate treatment): the patient is following both her nutrition plan and her rehabilitation program. She feels some changes in the pain, she cannot explain exactly which.

MARCH 2024 (3 months after Neridronate treatment): patient refers to a drastic pain decrease.

APRIL 2024 (4 months after Neridronate treatment): pain is still decreasing a bit every day. The patient feels her back/neck/shoulders situation has improved.

MAY 2024 (5 months after Neridronate treatment): her foot pain has settled on a 2 out of 10. She is generally better, and she does not need crutches to walk anymore.


This patient is very happy about the big changes that she is experiencing. She keeps on following the diet suggested from MTI nutritionist and she appreciates feeling generally better. She also exercises consistently and spend some time in open air every day. Her pain levels have dropped from an initial 9 to a constant 2, with still one month to go of possible improvements!

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.