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CRPS Treatment: pain in right leg for 4 years

General details and patient's info

Age:37 years old at the time of treatment.
Home Country:USA.
Illness duration:4 years prior to the Neridronate Treatment.
Cause:Skiing accident, fracture on tibia.
Symptoms:Burning sensation; extreme swelling of the foot; leg turns red and purple; can not wear long trousers as the skin is highly sensitive to any kind of touch; sensitive to changes in weather; depression.
Clinical evaluation:CRPS. 
Time of treatment:June 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient had tried various treatments, one of which unfortunately led him to an opioid addiction that pushed him to stop all type of medicine he was under, in May 2023. He then looked for other treatment options and was hesitant between Ketamine infusions and Neridronate. He organized a call with a member of our team, who explained in detail the drastic difference between these 2 types of treatments. The patient decided to come to Italy as soon as possible, a month after, he was welcomed for treatment.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Visits with the Health Coach.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by his Patient Manager, 2nd infusions. Visit with Health Coach

DAY 5: Rest day in the hotel, in contact with his Patient Manager.

DAY 6: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 7: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Pick-up by his Patient Manager, check-out, and drop-off at the Venice airport for his trip back home.

Follow up

SEPTEMBER 2023 (3 months after Neridronate treatment): The patient refers to an improvement of his symptoms of a general 20%. Upon advice from the team that followed him at the clinic, he has started to see a psychotherapist and says it has helped him a lot.

DECEMBER 2023 (6 months after Neridronate treatment): The patient now refers to a general improvement of 70% in all symptoms including pain levels, except for skin sensitivity which he happily reports has completely disappeared. He sends us a picture of him wearing jeans for the first time in 3 years.


The patient has managed to reach improvements of 60% on his condition, and the treatment allowed him to finally be able to wear pants on an area that was way too sensitive before, to any kind of contact.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.