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CRPS Treatment: pain in right wrist for 8 years

General details and patient's info

Age:65 years old at the time of treatment.
Home Country:United States of America .
Illness duration:8 years prior to the Neridronate Treatment.
Cause:Right wrist sprain.
Symptoms:Severe sharp pain in the right hand and especially in the wrist; burning and swelling; the patient manages to use her hand for her activities, but it is very painful.
Clinical evaluation:CRPS. 
Time of treatment:May 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient is a retired nurse, she quit her job at a clinic after she got CRPS, she was not able to go on with it. Being familiar with medical information and documentation she researched about all possible treatments. She was worried about travelling to Italy but finally she decided to try the Neridronate, after exhausting all the options in the USA, including a spinal cord stimulator, which failed to help her.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
8 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on next days.

DAY 2: rest day, in contact with her Patient Manager. Together with her caregiver the patient enjoyed a walk in Verona center.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Neridronate infusion.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. The patient feels well and she realizes that, thanks to the light therapy, the swelling is decreasing. Together with her Patient Manager she visits Vicenza center.

DAY 5: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. Lunch and walk in Soave, visit to the castle.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion.

Day 7: Day trip to Venice with the Patient Manager.

DAY 8: Rest day, in contact with the Patient Manager. The patient does some shopping in Verona, she feels well and never reported side effects.

DAY 9: Morning pick-up by her Patient Manager, drop-off at the Venice airport for her flight back home.

Follow up

JUNE 2021 (1 month after Neridronate treatment): the pain is still there but swelling fully disappeared.

AUGUST 2021 (3 months after Neridronate treatment): the patient says that her pain decreased about 40% and she may use her hand in a much easier and comfortable way. She has started to see a physical therapist.

SEPTEMBER 2021 (4 months after Neridronate treatment): the pain decreased of 70% and the patient feels generally much better.

NOVEMBER 2021 (6 months after Neridronate treatment): the patient says that the pain has almost disappeared, she feels it much less frequently.


This is a significant successful case. The patient reached near remission even though she was affected for 8 years. Rehabilitation therapy is essential in recovering from 8 years of being affected by pain, and the tolls it brings to one’s body.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.